After her parents are killed by bandits, young Sarasa Feed is sent to an orphanage where she learns about the prestigious world of alchemy. Determined to follow in her late parents' footsteps and become an independent business owner, she enrolls at the Royal Alchemist Academy to train and get certified as an official alchemist. Five years later, Sarasa graduates from the institution and nearly achieves her dream before realizing that she lacks the funds to do so. Left with little choice, she makes do with a low-priced storefront in a town situated far away from the bustling capital. Despite the threat of treacherous terrain and dangerous monsters in the remote countryside, Sarasa begins her exciting new life as an alchemist.

In the near future when technology has significantly advanced, a famous AI TV fortune teller seemingly foresees high school student Asahi Kashiwagi's day with pinpoint accuracy. On his way to school, he encounters Aoi Izumisawa, Bai Mongfa, Karin Istel, Amelia Irving, and Ilya Ilyukhin. Despite meeting them for the first time, Asahi suddenly receives love confessions from all of them at the end of the same day, perfectly aligning with the fortune teller's prediction. As if that was not enough, Asahi soon learns that these five individuals are actually candidates to become his bride, and they have been invited by his father to live at Asahi's home. Left with no other choice, he reluctantly allows them to stay, resulting in a bawdy turn of events that brightens up his average high school life. However, as Asahi spends more time with them, forgotten memories gradually resurface. While uncovering the hidden truth, Asahi begins to believe that his fate with these potential partners might be more than just mere coincidence.

Suletta Mercury leaves her planet and enters the Asticassia School of Technology at the behest of her mother. There, right and wrong are determined through duels between students, and the top-ranking duelist will receive Miorine Rembran as their fiancée—this prize being decided by Miorine's father. When Guel Jeturk, the best pilot in school and Miorine's current fiancé, demands that his betrothed move in with him, Suletta disapproves, so Guel challenges her. Although she emerges as champion, Suletta is subsequently detained on suspicion of piloting a forbidden type of mobile suit—a GUND-ARM, or "Gundam"—which results in her victory being voided. Miorine refuses to accept any more injustices and proposes another duel with even higher stakes. Now, Suletta must triumph a second time, otherwise she will be expelled and the Gundam Aerial that means so much to her will be destroyed.

High school girl duo Popuko and Pipimi are back and more unhinged than ever after their initial efforts to create a full-fledged anime production were met with a great reception. With no regard for their audience, they continue to live their reckless everyday lives consisting of comedy skits and parodies of epic proportions. No one is immune to the effects of their antics—including hapless live actor Shouta Aoi, who is on the run and stuck trying to be a hero in the wrong series.