Akane Nishimura's quiet nature makes her classmates perceive her as a gloomy and unlikeable person. Combined with her intimidating gaze, it earns Akane the ominous nickname "Grim Reaper," condemning her to endless bullying for her supposed cursed powers that bring misfortune to everyone around her. However, none of these rumors deter transfer student Taiyou Takada from trying to befriend Akane. As someone who finds the supernatural fascinating, Taiyou approaches the Grim Reaper without hesitation, blissfully unaware of the complicated situation within the class. His bright personality and optimistic worldview may just bring about the change that Akane desperately needs.

Under the belief that the omnipotent god Mitama will come to save him, Yukito Urabe participates in a ritual to become the new leader of his father's cult. But when the boy drowns during the ritual, he wishes to be reborn in a world without gods or religion. Reawakening in a completely different world devoid of spirituality. He meets a deviant girl named Aruaru, who introduces him to her village. However, his idyllic image of this world's society is short-lived when he witnesses a public group suicide and learns of the country's end-of-life system: at any moment, the government may order any citizen to die. Aruaru and her sister are forcibly taken for execution soon after, prompting Yukito to rush to their rescue—but to no avail. In a moment of desperation, Yukito recalls his father's teachings and utters a prayer for Mitama to save them. Seemingly answering his call, a little girl descends from the sky and annihilates everyone who harmed Yukito and his friends. To Yukito's surprise, the girl introduces herself as Mitama.

On his way to a convenience store, Kazuya Shiina tries to defend two young girls from an armed assailant, only to end up getting stabbed himself and dying on the spot. This good deed allows him to be reborn with all his memories in another world as Cain von Silford, the third son of a margrave. When Cain turns five, a baptismal ceremony in the church grants him an audience to the seven gods who preside over the world. Not only do the gods fill him in on the circumstances of his reincarnation, but they also give Cain their respective divine protections—allowing him to use cheat-like abilities in swordsmanship, magic, and many other aspects. With these blessings, Cain sets out to live a fulfilling life that he deems a dream come true. However, it soon becomes clear that the gods have more plans for him than just a haphazard bestowal of overwhelming power.

Far to the north of the world lies Hell's Gate, a portal formerly used by the Demon Lord to invade the human realm. Thanks to the legendary hero Shion Bladearts, wielder of Excalibur, and his loyal band of companions, the Gate was sealed off and the demonic threat was vanquished. Unfortunately, the seal was incomplete and has begun to weaken, allowing the demons to once again begin their attack. Worried about the safety of his village, selfish and perverted farmer Touka Scott dig pitfalls to defend against the demons. But fear not, for Shion is on his way to reseal Hell's Gate and save humanity! Or at least he was, because the legendary hero is dead, having fallen into one of the pitfalls Touka dug. Luckily, dealing with the dead is the specialty of necromancer Anri Haynesworth. While she can't revive him, Anri can at least salvage their quest by forcing Touka's soul into Shion's rotting body and dragging him along to Hell's Gate in Shion's place. Not wanting to be left behind, Touka's childhood friend Yuna Yunis tags along. Together, the three of them set out as what just might be the most unsuitable party to ever try to save the world!