On the planet Noman's Land, reporters Meryl Stryfe and Roberto De Niro traverse the desert in search of the infamous outlaw Vash the Stampede. But the man they find near the desolate town of Jeneora Rock is a far cry from the lethal terrorist they expect. In reality, Vash is a passive and carefree drifter; he is a proponent of peace, beloved by the residents of the town. His inaccurate reputation actually stems from the widespread atrocities committed by his twin brother Knives Millions. Still, Vash is dubbed "The Humanoid Typhoon'' due to the tendency for violent chaos to follow in his wake. Chaos soon arrives in the form of bounty hunters seeking the high price on Vash's head, and their violent pursuit poses great danger to the town and its precious power plant. Thanks to his gunslinging prowess, Vash is able to resist most of these nefarious forces. Yet he must soon face off against the ultimate evil: the unstoppable destructive power of his malevolent brother.

The anime revolves around a boy named Cota Coga (a wordplay on Coca-Cola) who strives to be the world's best Bottle King at the Bottle Battles in the virtual Drink World, with his Bottleman partner Colamaru and battles with various rivals. Bottleman! A new entertainment that has revolutionized the world! In the virtual space, Drink World, people use Bottleman to do bottle battles with one another! All strong bottle fighters aim to be the Bottle King!

After discovering that his orphanage was on the brink of closing due to financial stress, Finn, who was living freely on the streets, set out for a casino with the aim of making a fortune. However, nothing could have prepared Finn for the nightmare that was awaiting him. Once there, Finn encountered a car chase and bloody shootout caused by a man's "lucky" card. Finn will eventually learn what the shootout was about. The world order can be controlled by a set of 52 X-Playing cards with the power to bestow different superhuman powers and abilities to the ones that possess them. With these cards, people can access the hidden power of the "buddy" that can be found within themselves. There is a secret group of players called High Card, who have been directly ordered by the king of Fourland to collect the cards that have been scattered throughout the kingdom while moonlighting as employees of the luxury carmaker Pinochle. Scouted to become the group's fifth member, Finn soon joins the players on a dangerous mission to find these cards. "All you need in life are manners, dignity, and the will to bet on your own life." However, Who's Who, the rival car maker obsessed with defeating Pinochle, and the Klondikes, the infamous Mafia family, stand in the way of the gang. A frenzied battle amongst these card-obsessed players, fueled by justice, desire, and revenge, is about to begin! Are you ready? It's Showdown!!

Saenome are tasked with sealing spirits that possess objects and pose a threat to society. Known as tsukumogami, these spirits are generally non-violent, and saenome normally seal them after a simple verbal exchange. Traumatized by a previous deadly encounter with a malevolent spirit, Hyouma Kunato refuses to use peaceful methods and gets into physical confrontations with all tsukumogami that cross paths with him. Deeming this behavior unacceptable for a future clan leader, Hyouma's grandfather, Zouhei, proposes that he starts living with Botan Nagatsuki, a young woman whose family is composed of six tsukumogami—lest he be excommunicated. Determined to track down the spirit that took everything from him, Hyouma reluctantly accepts Zouhei's proposal. As unknown groups of evil spirits begin to jeopardize the balance between worlds, the young man must gain the trust of Botan and overcome his hatred for her mysterious family.