Each episode centers on Nuku Nuku's adventures and mishaps in high school, and her relationship to students, the overall series plot centers on the evil Mishima Industries' scheme to dominate the world through its products. In opposition to this plan are the slightly nutty Kyuusaku Natsume and Nuku Nuku, the android who acts as a companion to his young son. Nuku Nuku's classmates are all eccentrics, Futaba, the class president, is a domineering control-freak, who cannot leave her authority in school. Chieko Shirakaba is the rich snob with the two yes-girls who always take her side. There is a bookworm, a mystic, a scientist, and a pop singer. All of these are true to their descriptions: the mystic is always foretelling doom via tarot cards, spirits, or some other occult technique. The pop singer never says anything except as a song. The bookworm always has her nose in a book. These eccentricities add to the series' humor. (Source: ANN)

Ryuunosuke Natsume is the son of genius inventor Kyusaku Natsume and overbearing Akiko Natsume, CEO of Mishima Heavy Industries. Using funds from his wife's company and the brain from his son's beloved cat, Kyusaku creates a revolutionary android called Atsuko "Nuku Nuku" Natsume. To Kyusaku's disgust, Akiko wants to use her husband's technology to create weaponized robots for her company's customers, resulting in Ryuunosuke getting caught within the explosive fights between his parents The android Nuku Nuku tries to live as a normal high school student, adopting the role of Ryuunosuke's elder sister, but usually ends up acting as her family's protector. Nuku Nuku will do anything to protect the ones she loves. [Written by MAL Rewrite]

Originally from a big city, Futaba Ooki spends most days cataloguing her life through pictures on her phone. Upon moving to a seaside town, she gazes out over the vast expanse of sea and quickly becomes captivated by its endless possibilities. Unbeknownst to Futaba, her quiet contemplation catches the attention of local diving enthusiast Hikari Kohinata. Finding herself in the same class as Futaba the next day, Hikari is drawn to her quiet and shy demeanor and affectionately nicknames her Teko, sparking a tender friendship. Struggling to adapt to the change of pace in her life, Futaba finds herself strung along by Hikari's vast energy and passion for diving. Together, they join the school diving club, led by their homeroom teacher Mato Katori. With Hikari by her side, Futaba works to earn her diving certification while experiencing new friendships and possibilities. [Written by MAL Rewrite]

Bouida Haruto, a hardcore otaku with no interest in 3D (real) women, once appreciated figures from afar, accepting that "if you get into them, there's no turning back." However, when Nona, a character he loved from an anime called "Girls→Planetary Investigation" had a figure of her released, he ended up purchasing it. And then that night, the figure of Nona somehow came to life, and a couple-like lifestyle between man and toy began. (Source: MU)