The Yomota family is small and typical: father Kinekuni (42), mother Tamiko (38), and son Inumaru (17). One day, a beautiful girl appears at their front door, calling herself "Maroko Yomota," granddaughter of Inumaru who travels back in time with a time machine to visit her ancestors. Even with Tamiko's strong objection, Kinekuni and Inumaru welcome her to stay with them, and the structure of a happy family has begun to collapse.

For most people, wearing glasses is a necessity for clear sight, but for four young girls, their spectacles mean so much more. From a teenage girl wearing her glasses with pride and a top idol who uses hers to disguise herself as a regular person, to a couple whose bent frames bring them closer together, a good pair of glasses can not only open your eyes, but also open your heart.

In My Hero Academia: World Heroes’ Mission, a mysterious terrorist group called the Humanize are introduced. They strongly believe in the "Quirk Singularity Doomsday Theory." The theory states that as future generations continue to be mixed with the Quirk genes, the power it holds will lead to humanity’s demise. Furthermore, Humanize believes that Quirks are a disease, and so, they plan to “cleanse the world” by exterminating anyone who has one. Humanize planted "Ideo Trigger Bombs" in various countries, and these explosives are said to make a Quirk-user lose control of their Quirk, leading to mass destruction. To save and protect everyone, Pro-Heroes from around the world, and the U.A. Academy heroes-in-training, unite to thwart the efforts of the mysterious group.

After the defeat of Myouri Unzen at the hands of Medaka Kurokami and her Student Council, peace has returned to Hakoniwa Academy—at least, for a short while. Soon, Medaka, Zenkichi Hitoyoshi, Kouki Akune, and Mogana Kikaijima find themselves wrapped up in another sinister scheme, known as the "Flask Plan," led by the school's principal himself. However, the council's first problem is to deal with a whole new group of superhuman students calling themselves the "Thirteen Party," led by the egotistical but powerful Oudo Miyakonojou. With the mysterious Flask Plan, Oudo's tyranny, and the resurfacing of an old enemy, the state of Hakoniwa Academy is far from tranquil, and Medaka and her companions have their hands full as things only get a lot more abnormal. [Written by MAL Rewrite]