In the 24th Century, Intergalactic Space Travel has become a reality. One of the first outposts in the far reaches of space is WATCHER'S NEST - an inflation hole drive portal - which has recently come under attack by a mysterious force known simply as GHOUL... A group of young female cadets assigned to the portal are unexpectedly thrown into a hornet's nest of trouble as they finalize their training to become an elite pilot in the Seraphim Squadron. (Source: DVD Collection Back Cover)

Ruka and Rumi Kobayakawa are twin sisters in love with the same man, athletic upperclassman Katsuyuki Touma. Rumi seems supportive of Ruka's fledgling romance with Katsuyuki, until the twins are infected with a strange bacterium that transforms Rumi's personality and gifts the twins with terrifying psychic powers. Now Rumi will stop at nothing - or no one, that gets between her and Katsuyuki, including her own twin sister... (Source: ANN)

Juna Ariyoshi is an ordinary Japanese schoolgirl, who possesses a childlike curiosity and a strong admiration toward nature. One day, while on a trip with her boyfriend, Tokio Oshima, Juna dies from a motorcycle accident. However, she is given a chance to live by an individual named Chris Hawken. He offers her powers that make her the avatar of time; in exchange, she must fight to protect the Earth from evil forces called raaja, which are born out of the toxic pollution human beings have caused. She soon discovers that this is no easy task. While trying to master her newfound powers, she must also seek answers to deep questions about the ways science and technology have taken away humans' primal and instinctive connections with nature. With the help of Chris, his assistant Cindy Klein, and a powerful international organization named SEED, it is up to Juna to overcome her fears and find a way to stop the raaja from destroying everyone and everything she cares for. [Written by MAL Rewrite]

Lucy is a special breed of human referred to as "Diclonius," born with a short pair of horns and invisible telekinetic hands that lands her as a victim of inhumane scientific experimentation by the government. However, once circumstances present her an opportunity to escape, Lucy, corrupted by the confinement and torture, unleashes a torrent of bloodshed as she escapes her captors. During her breakout, she receives a crippling head injury that leaves her with a split personality: someone with the mentality of a harmless child possessing limited speech capacity. In this state of instability, she stumbles upon two college students, Kouta and his cousin Yuka, who unknowingly take an injured fugitive into their care, unaware of her murderous tendencies. This act of kindness will change their lives, as they soon find themselves dragged into the shadowy world of government secrecy and conspiracy. [Written by MAL Rewrite]