Among the high rises of steel pipes, meshed power lines, and faded neon lights, exists a game that children dare to play within the ruins of the old city. "Otokoyo," a secret game of hide-and-seek, one where all who play wear fox masks and only begins when seven have gathered. But it is no normal game, as all who have played it have gone missing. Many whisper it is the work of demons, but that is just a rumor... or is it? Kakurenbo follows the story of seven children as they play Otokoyo for the first time and discover why if you play, you never return.

The theatrical anime film is a full digital (3-D) action/horror film based on a manga by Tamaki Hisao, best known to Western fans for his manga adaptation of Star Wars: A New Hope. Characters were designed by Yasushi Nirasawa, a well acclaimed maker of creature action figures. Monkey Punch (Lupin III creator) served as the film's script superviser. Set in the year 2088, it depicts a dark future in which humans have been transformed into the "Guilstein," creatures with no human souls in them...

In the light of day and in the dead of night, mysterious horrors await in the darkest shadows of every corner. They are unexplainable, inescapable, and undefeatable. Be prepared, or you may become their next victim. Sit back in terror as traumatizing tales of unparalleled terror unfold. Tales, such as that of a cursed jade carving that opens holes all over its victims' bodies; deep nightmares that span decades; an attractive spirit at a misty crossroad that grants cursed advice; and a slug that grows inside a girl's mouth. Tread carefully, for the horrifying supernatural tales of the Itou Junji: Collection are not for the faint of heart.

Tired of Yuuko's antics for causing more ghost stories to be spread amongst the students, Kirie challenges her to a series of games which if Yuuko loses, she must behave.