Kyoshiro to Towa no Sora revolves around the life of Kuu Shiratori, a seemingly normal high school girl who enjoys her school life in the giant city Academia, which is thought of as a symbol of recovery for humanity since already ten years have passed since the greatest disaster mankind had ever seen, occurred. Kuu has recently been having a recurring dream where a prince meets her and takes her away. One day, while all the students at her school are preparing for the upcoming school festival, the prince, whom she has met several times in her dreams, appears. The prince, Kyoshiro Ayanokoji, requests of her just as he had done in Kuu's dreams, "Let's go... together..."

For Koutarou Murata, an overworked salaryman, his local ballpark is the only place where he can truly unwind from his arduous daily life. One evening, he is approached by Ruriko, the new lively beer vendor, trying to sell her first drink to him. Koutarou accepts Ruriko's offer, marking the start of their friendship and lots of playful teasing. While Koutarou tries to enjoy baseball to the fullest and Ruriko diligently seeks for more customers, many fans with heartwarming stories of their own come to fill the ballpark and enjoy the space that brings them all together.

Yusuke, an orphan, literally has Rouge, the amnesiac oldest daughter of the Underworld's deposed royal family, fall out of the sky into his lap. She is soon followed by her two younger sisters and also their family's enemies. Rouge must decide if she wants her memory to return, while Yusuke must deal with the upheavals in his life the Princesses have caused.

Takane Takamine is great at everything she does, and her magnetic personality makes her the envy of everyone. She gets good grades, excels at sports, and even manages to become student council president during her first year of high school. But Takamine has a secret—she possesses an ability called "Eternal Virgin Road," allowing her to redo past actions and achieve a different result. While this might seem like a decent skill to have, Takamine must pay a price to activate it: she has to strip off a piece of her lingerie. After getting an imperfect score on a test, Takamine begins to remove her underwear during class and is spotted by her average and weak-willed classmate Koushi Shirota, who is bewildered by the sight. However, the very next instant, things reset and Takamine's test is now perfect. When Shirota decides to confront Takamine about her previous test score, she reveals her ability to him and blackmails him into becoming her "closet," making him carry around extra lingerie and put them on her. Her goal is to be able to use Eternal Virgin Road as much as possible in order to stay at the top of the school hierarchy. Left with little choice in the matter, Shirota accepts, starting an oddly intimate type of relationship with the most popular girl at school.