Qiang Niang mainly tells of the protagonist Carrie, who has lost her combat memories, searching for herself and the story of her final "Awakening". In the years between 2025 to 2030, a world war involving the entire world has resulted in the demise of half the world's population, and humanity has already lost control of the direction the war shall go in. In order to seize ultimate victory, war has gradually been turned into a battle without people, similar to a game. War has already become about Satellite lasers, Bomb drones, Intelligent AI, a battlefield between unmanned gun turrets and tanks... Then, there are also a group of young maidens who uses outdated firearms to engage in battle —— the Gun Girls.

The story took place in the early days of the Sirius War. Newcomers on the battlefield fight bravely. Proving their value as a new generation of super-warriors on the front lines. However, when they followed their superiors, they were attacked by the Black Army, and the chiefs died. The battlefield fell and was forced to retreat. Comrades in the previous battle were just ordinary humans. They think that they died in the attack of the black army, but it turns out he survived.

Generations have passed since the war with the Space Monsters started, and none remain who know how it began, with even records of those times being scarce. It is a lost cause, but humanity still fights against them, relying on the "Topless": a group of elite space pilots with special powers that allow them to use the Buster Machines—the last hope against the Space Monsters. Nono, a girl from a remote Martian town, has heard tales all her life of the legendary pilot "Nono-Riri," and wants nothing more than to leave her humble life behind and follow in the footsteps of her idol. Though she has no idea of the dangers that lie ahead, nothing will stop her from achieving her dream. While Nono is down on her luck, she chances upon the lonesome Topless pilot Lal'C Melk Mark, and decides to stake her entire future on following Lal'C, no matter the cost. [Written by MAL Rewrite]

An animated spin-off from the Densha Otoko (Trainman) TV drama. In the drama, actor Itoh Atsushi plays the otaku Yamada, whose main love in life is the Mina anime, a cutesy busty heroine with floppy rabbit ears and carrots sticking out her rear. Mina itself is a character homage which triggers back to the Daicon Animation done by GAINAX where a similar nameless bunny girl appeared. Densha Otoko futher featured an opening with scenes which were appearing back in the Daicon Animation. (Source: AniDB)