After a disaster leaves the world in a state of decline, the remaining human population lives out their lives peacefully and quietly in the twilight of the human age. Alpha Hatsuseno is an android who works at a cafe bordering Yokohama that rarely gets visitors, and is waiting for her owner to return. One day, another android, the courier Kokone Takatsu, brings Alpha a package from her master. Inside is a camera, given to Alpha so she can take pictures to reminisce about. Yokohama Kaidashi Kikou is a slow and contemplative anime that follows an android girl as she takes beautiful pictures and experiences touching moments, all amidst a calming sense of peace.

In the near-future Japan, global warming has brought the large city Yokohama underwater, and only the hills remain above the ocean surface. What used to be one of the largest cities in Japan now feels like a small town. Basically, the existence of the island country itself has been threatened. However, there is no feeling of desperation, devastation, nor hopelessness. People are enjoying laid-back lives, and they seem to appreciate each other's company, enjoying the quiet and peaceful time together. This is especially so with Alpha, a carefree young woman who runs a cafe, named Cafe Alpha. She enjoys her life immersing herself in the beautiful nature all around her. There is nothing more precious to her than spending quality time with her kind friends. Oh, the fulfillment and the joy she finds in life... it all indicates her to be a compassionate human being, but she is not quite a human. She is actually a type A7M2 robot. One day, upon hearing a radio forecast warning an approaching typhoon, her old friend who lives close by invites her to the gas station he runs, worried that her old cafe may not withstand the typhoon. Indeed, the passing of typhoon leaves Alpha with her cafe severely damaged. That's when she decides to go on a journey to raise money to rebuild her cafe, and also to see the outside world away from her friends and the comfort of a peaceful life.

After an interplanetary war at the beginning of the 21st century, planet Earth has been left in ruins, with much of its ecosystem completely destroyed. Because it was no longer possible to live a normal life on this planet, the inhabitants are forced to move on to other planets where life will, hopefully, be more comfortable. The Deep Galactic Trade Organization, a totalitarian government that affects many of the newly inhabited planets, has somehow come to the conclusion that music is a source of evil, and that it must be banned and destroyed for good. The talent group AKB0048 is soon formed, based on the original AKB48 members that once lived on Earth. Even though their music is now considered universally illegal, they make it their mission to bring their music back to life by travelling from one planet to another and holding as many concerts as they possibly can. They must undergo a whole new set of training methods in order to become the best that they can possibly be, while also avoiding the constant danger of being arrested because of their music. Join interplanetary popstars AKB0048 as they try to save the world－with music!

The distant future. After reaching its peak, Earth's population fell into decline. AI was developed to help preserve the species and manage the ecosystem; a grand experiment in human diversity. Through genetic engineering, a diverse array of peoples, including beastfolk, magical beings, and more, was created to live in a diverse city separated into walled "clusters". Each cluster developed a unique culture, befitting of the people that lived there. Their lives, and the system, is continually maintained by the AI to ensure survival.