In a near future, an illness called "Cagaster" made ​​its appearance. It turns humans into insects. The story begins 30 years after the onset of the illness, in 2125. It follows the adventures of Kidou, a boy who fights insects.

After fending off the threat of a Neuroi invasion of Romagna and destroying the enemy's nest over Venezia, Yoshika Miyafuji goes back to her home town in the Empire of Fusou. Despite the loss of her magical and healing abilities, the former officer of the 501st Joint Fighter Wing wants to continue studying medicine. This is in order to help those in need, both civilians and those on the front lines alike. She receives an invitation from a prestigious school in Europe and decides to accept the offer, embarking on a journey back to the war-torn continent. However, a new danger arises, as more and more Neuroi manage to break through human defense lines, appearing unnoticed in supposedly safe areas and disturbing the balance of power in Europe. Yoshiki's sense of duty collides with her inability to pilot a Striker Unit, but with her friends in peril, it seems that there is only one thing she can do.

Cyberpunk: Edgerunners tells a standalone story about a street kid trying to survive in a technology and body modification-obsessed city of the future. Having everything to lose, he chooses to stay alive by becoming an edgerunner—a mercenary outlaw also known as a cyberpunk.

Takato and Guilmon go on vacation to Okinawa and meet a fellow tamer, Minami. Back in Japan, a popular computer pet suddenly becomes a virus, infecting all of the computers who have it. As the virus spreads, Takato tries to figure out why digimon are all attacking his new friend, and what her connection is to the virus.