E-Rantel, the capital city of the newly established Sorcerer Kingdom, suffers from a dire shortage of goods. Once a prosperous city known for its trade, it now faces a crisis due to its caution—or even fear—of its king, Ainz Ooal Gown. To make amends, Ainz sends Albedo to the city as a diplomatic envoy. Meanwhile, the cardinals of the Slane Theocracy discuss how to retaliate against Ainz after his attack crippled the Re-Estize Kingdom's army, plotting for the Baharuth Empire to take over the Sorcerer Kingdom. However, when Emperor Jircniv Rune Farlord El Nix arranges a meeting with the Theocracy's messengers at a colosseum, he is confronted by none other than Ainz himself. With their secret gathering now out in the open, the emperor and his guests learn that Ainz has challenged the Warrior King, the empire's greatest fighter, to a duel. With Ainz's motivations beyond his comprehension, Jircniv can do nothing but watch as humanity's future changes before his very eyes.

Kou Yamori is an average middle school student who struggles with grasping the complex concept of love. Because he sees little sense in surrendering to the norm, he soon stops going to school. Plagued with insomnia due to his idleness, Kou begins roaming the lonesome streets at night. One night, Kou encounters a bizarre girl named Nazuna Nanakusa who believes that people stay awake during the night because they are dissatisfied with how they spent their day and cannot rest until they release their inhibitions. Nazuna offers to help Kou with his sleep issues and invites him over to her place, where she convinces him to share a futon with her. Feeling uncomfortable, Kou only pretends to doze off—which is when Nazuna suddenly bites his neck and reveals herself to be a vampire! While Kou thinks the bite will turn him into a vampire, the specifics of transforming are not that simple. In order to change, he must be bitten by someone he truly loves. Ready to let go of his dreary mortal life, Kou decides on a new goal: he will fall in love with Nazuna and become a vampire.

Yuuta Okkotsu is haunted. Ever since his childhood friend Rika died in a traffic accident, her ghost has stuck with him. But her spirit does not appear as the sweet girl Yuuta once knew. Instead, she manifests as a monstrous and powerful entity who fiercely protects him. Unable to control Rika's violent behavior, Yuuta is helpless to stop the bloodshed that follows from her brutal vengeance. As a result, when apprehended by "Jujutsu" sorcerers—the secret guardians of the world, trained to combat forces like Rika—Yuuta wishes to be completely isolated so that no one else can get hurt. Yet his apprehender, the master sorcerer Satoru Gojou, has different plans for him: he will join Jujutsu High School and learn to control Rika in order to help people. Now a first-year at this school, Yuuta starts to learn Jujutsu arts and combat malignant beings. Alongside his new classmates Maki Zenin, a Jujutsu weapons expert; Toge Inumaki, a spellcaster who uses his words as weapons; and Panda, a seemingly walking and talking panda bear, Yuuta begins to find his place in the world and, for once, to feel comfortable with his abilities. However, as his training progresses, Yuuta comes to learn that the dangers of the Jujutsu world go far beyond that of wicked spirits.

In 1868, Dario Brando saves the life of an English nobleman, George Joestar. By taking in Dario's son Dio when the boy becomes fatherless, George hopes to repay the debt he owes to his savior. However Dio, unsatisfied with his station in life, aspires to seize the Joestar house for his own. Wielding an Aztec stone mask with supernatural properties, he sets out to destroy George and his son, Jonathan "JoJo" Joestar, and triggers a chain of events that will continue to echo through the years to come. Half a century later, in New York City, Jonathan's grandson Joseph Joestar discovers the legacy his grandfather left for him. When an archeological dig unearths the truth behind the stone mask, he realizes that he is the only one who can defeat the Pillar Men, mystical beings of immeasurable power who inadvertently began everything. Adapted from the first two arcs of Hirohiko Araki's outlandish manga series, JoJo no Kimyou na Bouken follows the many thrilling expeditions of JoJo and his descendants. Whether it's facing off with the evil Dio, or combatting the sinister Pillar Men, there's always plenty of bizarre adventures in store.