Jolyne has achieved her mission in retrieving Jotaro Kujo’s Star Platinum Disc and his Memory Disc, thus saving her father’s withering life, but in standard JoJo fashion, the forces of good do not stop once they’ve completed their original objective. When there is evil in the world, it needs stopping, so Jolyne will not stop at anything to stop Pucci, with the help of Ermes Costello and Emporio Alnino.

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.

Despite standing at the zenith as the strongest exorcist, Haruyoshi Kuga sought even greater power, which led to his demise at the hands of those who envied his might. As he draws his last breath, he casts a spell that allows him to reincarnate and swears to become more cunning, hoping that all his efforts will prove useful in his next life. Haruyoshi is soon reborn in another world as Seika Lamprogue, an illegitimate son of a noble family that prides itself on magic. However, his new family largely ignores him due to his lineage and magic deficiency. Nevertheless, the unbothered Seika leverages the knowledge from his previous life to make numerous valuable allies. As he begins to explore the true limits of his abilities, Seika must also be wary of the consequences that tarnished his past and avoid repeating the same mistakes.

Disillusioned with the afterlife, a new student causes a scene during a classroom test and expresses his doubts about whether getting good grades can really lead to escaping the school and ascending to Heaven. Afterwards, he is confronted by the new student council president—a familiar face whose past experiences give him powerful insight into the true nature of the school and first-hand knowledge regarding the futility of rebellion. [Written by MAL Rewrite]