Self-professed "home security guard" Mahiro Oyama has not left his home in years, secluding himself in his room playing erotic visual novels. This depraved lifestyle causes his prodigious sister, Mihari, to worry about his well-being. In hopes of solving this problem, she devises a plan to rehabilitate him back to normalcy. The first part of Mihari's plan is to concoct a medicine that changes her brother's biological constitution into a bona fide female, much to Mahiro's vehement dismay. Stuck in this predicament, Mahiro has no choice but to live out his life as a cute girl until the effect wears off—if it ever does.

Determined to pursue his glorious childhood dreams, 30-year-old Rick Gladiatol, a modest clerk in the adventurers' guild, is offered a once-in-a-lifetime opportunity after he fatefully encounters the dark elf Reanette Elfelt. Reanette happens to be an elite adventurer of the legendary party Orichalcum Fist, whose members welcome Rick under the condition that he follow a Spartan training. Two years later, Rick is finally ready to take the E-Rank exam officially qualifying him as an adventurer. However, raw magical power can only be developed until one turns 20. As such, Rick faces the general hostility of fellow participants and examiners alike, leaving him no choice but to show the world that his hellish training has turned him into an invincible warrior.

Gintoki and his Yorozuya friends (or rather, employees suffering under labor violations), Shinpachi and Kagura, continue to scrape by in the futuristic, alien-infested city of Edo. They take on whatever work they can find while trying not to get involved in anything too dangerous. But when Katsura, the leader of the Joui rebels and Gintoki's long-time acquaintance, disappears after being brutally attacked by an unknown assassin, Shinpachi and Kagura begin an investigation into his whereabouts and the identity of the assailant. Meanwhile, Gintoki takes on a seemingly unrelated job: the blacksmith Tetsuya requests that Gin recover a strange and powerful sword called the Benizakura which was recently stolen. As the two investigations gradually intersect, the Yorozuya crew find themselves in the midst of a major conspiracy that hinges on the sinister nature of the Benizakura sword. Gintoki resolves to take the fight directly to the enemy headquarters, and together with a few unexpected allies, sets out on one of his most perilous jobs yet. [Written by MAL Rewrite]

Ever since the 10th NOVA clash, the Chevalier had concluded that the NOVA have been appearing at a steadier rate and they are losing more Pandoras than they can produce. Their solution is the E-Pandora Project which involves normal humans being given the power to become Pandoras. Inviting Pandora from around the world to their Alaskan base witness the unveiling of their new project, Satellizer, Kazuya and Rana are among those who have been summoned. However, as time goes the E-Pandora Project starts to become fishier and the Pandoras start to grow more and more concerned...