The story is set on Okinawa's isolated island of Iwado, which has seen a growing movement advocating a return to an autonomous government. Ao Fukai, a 12-year-old boy with a missing father, lives on the island with an old doctor named Toshio and is about to enter middle school. Ao's mother was taken away a decade ago by unknown individuals. Naru Arata, Ao's 12-year-old childhood friend and the story's heroine, lives with her father, older sister, and grandmother. She has a "Yuta" power awakened within her due to an incident when she was young. A mysterious entity called "Secret" suddenly appears and launches an attack on the Scub Coral lifeform on the island. Ao launches a certain military FP called "Nirvash" aboard a Japanese military transport in his fervent desire to protect the island. (Source: FUNimation)

It was officially announced at the Dengeki Game Festival 2015 event that Strike the Blood will be getting a two-episode OVA series to be released at the end of 2015. The OVA will be an original story written by Gakuto Mikumo.

Specials included with the Blu-ray/DVD volumes.

In a futuristic world, the Maruhage Empire is a militant organization out to steal everyone's hair, and thus their freedom. But a brave man with an afro of gold and nose hairs of steel stands up against their tyranny. Bobobo-bo Bo-bobo, trained in the ways of hair, rescues a teenager named Beauty from the grunts of the Maruhage Empire. Together, they start on a journey to defeat Emperor Tsuru Tsurulina IV. As Bo-bobo meets new friends and battles foes along the way, so too does he begin his quest to save all the hairs of the world! Light-hearted and comical, Bobobo-bo Bo-bobo details a wacky adventure in which Bo-bobo and his companions fight all sorts of villains and deviants within the Maruhage Empire, all the while having a fun and exciting adventure. [Written by MAL Rewrite]