Abandoned as a child by her mother, Aoi Tsubaki has always had the ability to see "ayakashi"—spirits from the Hidden Realm. Shirou Tsubaki, her grandfather who shared the same ability, took her under his wing and taught her how to live with the ayakashi in peace. When her grandfather abruptly passes away, the independent Aoi must continue her college career, armed with only her knowledge in cooking as a means of protection against the human-eating spirits. In hopes that the ayakashi will not turn to her or other unknowing humans as a tasty meal, she takes it upon herself to feed the hungry creatures that cross her path. After giving a mysterious ayakashi her lunch, Aoi is transported to the Hidden Realm, where the ayakashi reveals himself to be an ogre-god known as Oodanna, the "Master Innkeeper." There, she learns that she was used as collateral for her grandfather's debt of one hundred million yen, and that she must pay the price for her grandfather's careless decision by marrying Oodanna. Aoi valiantly refuses and decides to settle things on her own terms: she will pay off the debt herself by opening an eatery at Oodanna's inn. Kakuriyo no Yadomeshi follows the journey of Aoi as she proceeds to change and touch the lives of the ayakashi through the one weapon she has against them—her delicious cooking.

Azusa Kannawa, ace of the publicity department, is known for her unmatched reliability. Her coworkers, on the other hand, find her no-nonsense demeanor intimidating. Yet, unbeknownst to them, a socially awkward woman hides underneath the facade, simply struggling with casual communication and masking it with a strong attitude. However, her mask begins to crack when a promising rookie, Yuu Kamegawa, joins the team and Azusa gets assigned as his mentor. Determined to guide Kamegawa just like how her senior once trained her, Kannawa puts utmost effort into showing him the ropes. But as they grow closer, she slowly lowers her guard, gradually revealing that the seemingly rigid department ace might actually be far kinder than anyone initially thought.

Ever since horse girl Oguri Cap left the small town of Kasamatsu to chase greater heights in Tokyo, she has rapidly gained attention with her remarkable results. Her goal to become the best horse girl in Japan seems within reach, but there is a rival in her way—another running prodigy named Tamamo Cross. However, Tamamo is not the only threat to Oguri: several world-class racers from overseas are joining the Japan Cup, pushing the renowned race's competition to unprecedented levels. With the support from the people close to her and her intense desire to win, Oguri will do anything to conquer the Japan Cup and continue sprinting for the top.

Saku Chitose appears to lead an enviable high school life. Extraordinarily charismatic, tremendously confident, and effortlessly friendly, he is the kind of person others naturally look up to. But his popularity carries its own burdens; not everyone views him kindly, and whispers of cynicism follow wherever he shines too brightly. To Saku, living an ugly life is worse than death—a belief that drives his need to maintain his perfect reputation. At the start of his second year, Saku's homeroom teacher asks him to help bring back a classmate who has stopped attending school. Initially hoping to resolve the matter quickly, Saku finds out that the shut-in Kenta Yamazaki harbors open contempt for him and everything he represents. A simple favor instead exposes the distance between those who live within the social light and those who were never given a chance to shine. Surrounded by the expectant gazes of those who both admire and despise him, Saku treads the delicate line between sincerity and performance—searching for what it truly means to live beautifully in a world that sees only the surface.