Amawa Hibiki is a young man just out of college, with an education to be an athletics teacher. He's been having a hard time finding a job since he graduated, so all his money has gone towards living expenses. When his landlady demands his first payment to live in her living establishment upfront, he heads to the local middle school to get hired as a teacher. However, the principal refuses to hire him without hesitation. She will not hire men as teachers and makes it clear that she hates all men, saying they put no love into their passions and work. Amawa does not give up and with the help of his landlady, he crossdresses as a woman without a second thought, and gets hired, so he can earn money and also prove the principal wrong. Now, he has to keep his real gender a secret, and avoid strange situations, including the affections of his students (from both genders).

Human beings can be divided into two kinds: ordinary people who work for the living, and the undead who work for the dead. For the undead, their lives are dedicated to fulfilling the final wishes of ghosts who died with regrets. As for Baili Dengfeng, he has one and only one destiny in this world: to find his long-missing wife Ruyan. During his quest, Dengfeng makes acquaintance with Jia Xuan, whose family was murdered and is yet to be avenged, Liang You who is cute, naughty and adores him very much, and Liang Yuan, who simply doubts everything neurotically. After a series of events, he also learns of the existence of Spirit Masters and Spirit Slaves, and gets in touch with a mystical organization named "Spirits Expelling Order". With more and more mysteries being unveiled, the truth is drawing closer and closer to Dengfeng, who perhaps would rather not face the whole of it.

The story takes place in Tokyo Butei High School, a special school where armed detectives—"Butei"—are trained to use weapons. Kinji Tooyama is a second-year-student who has a special ability, but he keeps it a secret to maintain an ordinary, peaceful life; however, when he gets caught in a bombing on the way to school, he encounters H. Aria Kanzaki, the most powerful S-Rank Butei student in Assault Studies.

The official Twitter account for the Gundam Build Fighters and Gundam Build Fighters Try television anime reported on Wednesday that original video anime (OVA) projects are launching. According to the producer in charge of the account, director Kenji Nagasaki is planning one Gundam Build Fighters OVA, and director Shinya Watada is planning one Gundam Build Fighters Try OVA.