In the 24th Century, Intergalactic Space Travel has become a reality. One of the first outposts in the far reaches of space is WATCHER'S NEST - an inflation hole drive portal - which has recently come under attack by a mysterious force known simply as GHOUL... A group of young female cadets assigned to the portal are unexpectedly thrown into a hornet's nest of trouble as they finalize their training to become an elite pilot in the Seraphim Squadron. (Source: DVD Collection Back Cover)

Two scientists are attempting to distribute the cure for a demon virus that is affecting people all over Japan, however, things have become complicated. One of them has become infected. So begins his battle with himself, as he attempts to not only control his emerging demon side, but also to save the lives of others by wielding its great strength.

Aika's story continues, she is now 19 years-old, 3 years older than in R-16 and 7 younger than in Agent AIKa. Strange phenomena have been occuring at a girls academy. Slowly but persistently the most cute and beautiful girls are joining an internal club, but instead of a sing-in they just get abducted by a strange being that takes control over them by some indecent means. By coincidence Aika was flying-by on her plane when one of this abductions occurred and she was attacked to prevent her from comming closer, but instead of repelling her, she is intrigued about the attack's origin and then the opportunity shows up when her late partners from R-16 decide to investigate those abductions. The story remains full of action and panty flashing that are a must in Aika's series.

A catastrophic earthquake has left Tokyo, and most of the Earth for that matter, under the sea. Aika is a salvager who retrieves various remains from the watery ruins. When Aika accepts the dangerous mission of locating and obtaining the mysterious Lagu, she discovers that she's not the only one after it.