In the Edo period, there was a shrine maiden called "Itsukihime" in the mountain village of Kadono. Jinta, a young man who acts as the shrine maiden's guardian despite being a stranger, encounters a mysterious demon who speaks of the far future in the forest where he went to defeat it. From Edo to the Heisei era, this huge Japanese fantasy series follows a demon man who travels through time while continuously questioning the meaning of wielding a sword.

Life hasn't been kind to Zenos. He was born in the slums, and his dirt-poor background has denied him almost every opportunity. After an encounter with a healer, he throws himself into studying to become one and finally catches a break when an adventurer invites Zenos into his party. Zenos is thrilled—so thrilled, in fact, that he's willing to put up with his teammates treating him like garbage. They fail to appreciate his talents and ultimately kick him to the curb, claiming he's outlived his usefulness to them. Now bereft of money and out of options, Zenos decides to put his self-taught skills to use elsewhere and opens an underground clinic. Word quickly spreads about the brilliant healer working incredible magic in the city's shadowy underbelly. Even the royal palace is taking notice... Can Zenos buck the odds and carve out a life for himself in a world that's spit in his face? And can he save the lives of the patients who wind up on his doorstep in the process?

Nico Wakatsuki has finished her six years of witch training and is moving back to town by herself. As a new witch, she must choose a familiar to accompany her. However, unlike the other witches, she wishes to pick a non-animal familiar. There's no better companion than Morihito "Moi" Otogi—her childhood friend who happens to be an ogre. Morihito is vehemently opposed to being her servant, but he reluctantly accepts his fate after learning that a curse would revert him into a strange cow-tiger hybrid were he to disobey a witch's order. Due to Morihito's father leaving for a business trip and Nico's mother remaining behind in the Witches' Holy Land, the two teens find themselves living together under the same roof. While Nico is ecstatic to be living with her crush, Morihito finds that her magical antics and overall clumsiness create more problems than solutions. With a prophesied disaster to befall Nico within the year, Morihito must do everything he can to protect her as her bodyguard while also upholding his duties as her familiar.

Beryl Gardinant, a self-proclaimed "humble old man," is a sword instructor at his dojo in a rural, backwater village. In his younger years, he dreamed of glory as a master swordsman, but those days are long behind him. Out of the blue, he receives a visit from a famous former pupil who brings him world-shattering news—he's been appointed as a special instructor for the knights of the Liberion Order! With his life now turned upside down, Beryl travels to the capital and reunites with some of his former students: elite knights, an ace wizard, and even an adventurer who's attained the highest guild rank possible. But why do they all want his tutelage?! As far as he's concerned, they clearly don't need him anymore. Can Beryl live up to his new position? And will he ever get a moment's peace away from his adoring students?!