Waking up transformed into a beautiful girl might be the stuff of some guys' fantasies, but when the suddenly effeminatized Natsuru is informed by a stuffed tiger that he's now a Kampfer, a mystical fighter who has to fight other Kampfers in female form, his life becomes a living nightmare! Putting aside the obvious "plumbing" issues, Natsuru's best childhood friend turns out to swing the other way and SHE has a crush on his new female body. Not complex enough? Natsuru's school has separate sections for boys and girls, so he and she are now double enrolled. The rumor-mill has it that he's dating herself. And there are other Kampfers attending the school who want to take her out, and he's not sure which ones mean "on a date" and which ones mean "permanently." Oh, and did we mention that some Kampfers use swords and guns?! Hormones, fists, and other body parts will fly as the daring, new gender-bender defender must become a contender or die! (Source: Sentai Filmworks)

500 years ago in the Tensho Era of Japan, a man was born who defied the will of a demon; a man who had gods of good on his side; a man destined to battle evil....his name was Kabuto. Somehow, Kuroyasya Douki, the vile Black Night Demon, escaped his prison in hell and returned to the earthly plane to wreak vengeance on the family-line of Kabuto. None can escape his deadly magic and masterful skills with the blade; however, the gods of the North, West, East, and South band together to help Kabuto stand for Justice. With the questionable help of a diabolical talking sword that his own father forged, Kabuto may live another day to see his own sons born....

The anime follows a group of friends Giulia, Maria, Enrico, Lucio and Angelon during the disaster as they team up with a Japanese journalist Shiro Ando, and begin their own investigation of what's occurring (during the week long period of exposure when the ICMESA refused to notify citizens of the poison). As many animals are dying and people are getting sick. The children and Shiro discover deadly dioxin was released and inform Enrico's father, the town mayor, who evacuates all the citizens. Shiro continues investigating more and learns of the negligence of La Roche, a company who controls ICMESA. La Roche knew they were in violating of existing safety laws/protocols and destroyed evidence of their crimes. The children attend a press conference to ruin La Roche's reputation as the destroyed proof might not be enough in a court of law to punish them. Giulia's pregnant sister, who opted to not abort, gave birth to a healthy girl. The happiness is short lived, as the baby prematurely dies from dioxin poisoning.

Short specials included in the Blu-ray Box 1 & 2 of Gundam Build Fighters. Episode 1: SD Kishi Fighters First Half Episode 2: SD Kishi Fighters Second Half Episode 3: A Letter