Onboard a cruise ship heading to the scenic Cenancle Island, the full-body cyborg Nene Nanakorobi, a bubbly young girl who dreams of world peace, meets inventor Uzal Delilah. The two become fast friends along with Uzal's pet cyborg Clarion, a cat-like combat android. Soon after parting ways, a terrorist attack on the island threatens to shatter the pair's new friendship. In a bid to save her new friend, Uzal gives Nene the ability to use the Pandora Device found in Clarion's body before seemingly dying. With this power, Nene can temporarily master abilities and skills never seen before in the advancing world. Working together, the two unlikely companions go on various missions—from saving children in shopping mall fires to fighting reckless thieves—all in the name of world peace. But to achieve this goal is not easy. B.U.E.R, a sentient laser in the form of a misshapen teddy bear, threatens to wreck their happy lives with his perverted nature and uncontrollable power. And to make matters worse, Nene's guardian, as well as genius inventor, Takumi Korobase has an undying interest in B.U.E.R. Burdened with saving the world and keeping B.U.E.R from the hands of evil, Nene and Clarion's desire for world peace seems like a pipe dream. With this monumental goal, could the weight of it all destroy the pair's friendship completely?

The series is a historical drama aesthetically and boldly adapting the life of Oda Nobunaga in his teens up to his time as a warlord against his brother, Nobuyuki.

The series is set in the distant future in which the Earth is split in two. The southern hemisphere is placed in another dimension while the inhabitants of the northern hemisphere are able to morph into beast-like humanoids. Eventually the humans of the southern hemisphere, led by Uranus, attack the Beasts. The Three Beasts, Wan Derbard (Wan Dabadadatta) of the Tiger Tribe, Bud Mint (Baado Mint) of the Bird Tribe, and Mei Mer (Mei Mah) of the Mermaid Tribe, are taken prisoner along with Mei Mer's companion Tuttle Millen (Mekka Mannen, also of the Mermaid tribe), but manage to escape thanks to a little girl named Yuuni Charm Password. Together they seek Gaia, which they believe to be a fabulous treasure, but they are pursued by Uranus's minions : V-Darn the vicious mage-knight, V-Sion the warrior woman and Akumako, V-Darn's sadistic imp-like partner.

It is 199X A.D. In Kushiro, Hokkaido, three bodies of Dragonite appear. Possessing overwhelming destructive force, they attack the city. They also awaken the evil Jashin Drago from the holy seal he was trapped in. 200 years ago, Drago was trapped in the seal by a holy warrior with the tattooed mark of the Liger. Assuming that the warrior is dead, Drago and Empress Zara are free to conquer the Earth using their army of biomechanical beasts. Even the Japan Self-Defense Forces are no match for the Dragonites' awesome power. One of the people fleeing is the protagonist, a milquetoast 16 year old boy named Ken Taiga. Unbeknownst to the Dragonites, Ken realizes that he is the descendant of the Liger warrior! In a burst of anger, Ken's Liger birthmark appears, and he rises his palm into the air, shouting the henshin command, "LIGER!!!", which then covers him in demonic long-haired biomechanical armor. Ken transforms into Jushin Liger to fight the evil forces of the Dragonite!