Despite having accomplished a lifelong dream of hers, Ann Halford faces further challenges ahead. Bridget Paige, the daughter of the Paige Workshop's owner, still possesses the wing of Shall Fen Shall, Ann's former fairy companion. In determination to save Shall from the obsessive Bridget, Ann decides to join the Paige Workshop, hoping at the same time to perhaps reunite with her close friend. Having been appointed head of the workshop, Ann becomes entrusted with rebuilding it to its former glory. She quickly discovers that the Paige Workshop has a unique focus on tradition and individuality, and recognizes that she will need to learn about her team and completely revamp the workshop in order to succeed. Motivated by her strong desire to rescue Shall and her obligations as a sugar artisan, Ann wholeheartedly dedicates herself to her new position.

From her hometown to her daily life on Kurken Island, everything surrounding Reisalin "Ryza" Stout is painfully ordinary. Despite being the daughter of a hardworking farmer, she would rather go on pretend adventures as she explores almost every corner of the island. However, the fact that it is against the local customs to venture off Kurken Island irritates her to no end. One day, wishing for something interesting to finally happen in her life, Ryza escapes on a boat with her two good friends: the bookworm Tao Mongarten and the aspiring warrior Lent Marslink. Arriving at a nearby forest, the trio stumbles into Klaudia Valentz, the daughter of a visiting merchant who also wandered off into the woods. As the naive and underprepared group ventures further, they run into dangerous monsters. Thankfully, they are rescued by the alchemist Empel Vollmer and his skilled bodyguard Lila Decyrus. This fateful encounter will lead Ryza to the key that will change her life forever—the creative and wonderful world of alchemy.

Three months have passed since the Demon King was defeated by a hero. Mankind rejoices over their victory, but dwellers of the demon world do not share the same sentiment. With the loss of their king, they must now hold a tournament to decide who will become his successor. Monitoring the competition is the hot-headed yet powerful Vamirio—one of the Four Heavenly Kings. Among all the participants, she is extremely distrustful of one: Helck, a human hero who claims to hate humanity. As much as she wants to get rid of him, it is impossible due to Helck's incredible strength and popularity. Amidst the competition, Vamirio discovers that humans have vanished from various towns. As a result of this puzzling turn of events, Vamirio grows desperate to reveal Helck's true intentions by carefully crafting a plan to make Helck lose. If she proves to be successful, she might uncover where his loyalty truly lies before the demon world is endangered.

In 19th-century France, the wife of vampire noble Jean Duchet Godard is murdered in her own home. With the local human authorities unwilling to properly investigate the case, Godard hires a pair of private detectives known to specialize in the supernatural: Tsugaru Shinuchi, a man with a mysterious birdcage; and his partner, Aya Rindou. This enigmatic duo has come from faraway Japan for one purpose—to track down the man who stole both Aya's body and Tsugaru's humanity.