The anime series is set in the future when humanity migrated to the Moon due to Earth's climate change. It will incorporate original elements unique to the anime, such as human drama about survival, and will feature a diverse field that blurs countries and eras such as Shibuya, the Edo-period era, and London.

Because of the legend left by Tatsuya Uesugi, Meisei Academy High School was well-known for their strong baseball team. But 26 years after their glory, the team has not been able to keep their record and has since lost their fame. Two stepbrothers, Souichirou and Touma Tachibana, aim to revive of the once-strong Meisei Academy baseball team and enter the National High School Baseball Championship. Souichirou and Touma are second years in Meisei Academy Middle School. Both boys are talented baseball players. Souichirou has shown excellent skill as a catcher and batter. Though having an extraordinary skill as a pitcher, Touma no longer pitches due to a certain reason. Once the two enter high school, they pair as a battery and aim to enter the National High School Baseball Championship!

In the 20th century, the world is experiencing a musical theater boom. Top performers known as Dai Stars enthrall the audience with their marvelous acting and singing. Among them, the greatest performers are given the title World Dai Star. Young and inexperienced Kokona Ootori dreams of being recognized as a World Dai Star. After multiple failures, she finally gets another chance to audition for the world-renowned theater troupe Sirius. Inspired by her best friend Shizuka, Kokona takes the first steps toward her goal and works hard to improve her acting. However, the world of theater is fiercely competitive, as many other girls seek the spotlight—including Kathrina Griebel, a talented performer from Germany. In order to fulfill her dream, Kokona needs to earn the right to stand on stage above all else.

In a world of magic and monsters, Krylancelo Finrandi and his foster sister Azalie Cait-Sith were once promising students of sorcery, prodigies at the famous Tower of Fangs. But an experiment gone horribly wrong warps Azalie's appearance, trapping her in the form of a dragon. Elders at the Tower—more interested in preserving their reputation rather than their students' lives—drive off the transformed Azalie and cover up the incident. Outraged, Krylancelo strikes out on his own, taking the new name of "Orphen" and vowing to return Azalie to her normal state. Five years later, Orphen's quest has stalled. A chance encounter brings him face to face with Azalie again, but he still has no way to restore her body. And with a hostile group of sorcerers hunting her down, he may be running out of time. The past and present collide as Orphen tries to find how to save Azalie from their former teachers and friends.