As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.

Mitsuo encountered Superman, an alien who is a part of a federation that tries to maintain peace in the galaxy. He then received a helmet (that also serves as a mask) that gives superhuman strength, a cape that enables the wearer to fly, and a badge that allows him to breathe underwater and communicate with his fellow comrades whom he met soon after he utilized these gifts. Superman made it clear to all Permans that their identity must be kept a secret or their brain will be destroyed should it ever be revealed and they are given a special doppelganger robot that can replace them while they are away to achieve this feat, although it is not entirely foolproof nor is it free from potential problems. These equipments then allowed them to be young Permans who try to maintain peace and help the people who are in need. (Source: ANN)

There is Earth, our familiar world, and then there is the Black World, a parallel dimension that very few people are aware of. For centuries, a pact between the two worlds has been observed to maintain peace, and terms must be negotiated and renewed soon to continue relative harmony. This time around, there is a militant faction that will stop at nothing to prevent the signing of a new treaty for inter-dimensional peace. Two agents of the elite organization known as the Black guards—defenders of the balance between the two worlds—are charged with ensuring the success of the treaty. Director Yoshiaki Kawajiri (Ninja Scroll) blends stylish eroticism, graphic horror and pulse-pounding action as these two race to consummate the peace treaty in time. (Source: AniDB)

There's a crisis in the Chinese Spirit World -- humans don't believe in gods anymore! A Door God, facing unemployment, ventures into the human world to prove his worth, leading to unexpected encounters and transformations for humans and spirits alike.