Due to her mother's work, Chizuko Date has never remained in one place for long or grown attached to anything in particular. However, while temporarily staying with her grandfather Suikyou, she witnesses something extraordinary: a magical girl named Berry Blossom fighting against Chroma, member of the evil organization Fossa Magna. Seeing Berry Blossom save the day ignites a passion in Chizuko, and she swears to be a fan of the new magical girl in town thereafter. As time passes, Berry Blossom's popularity dwindles due to the incompetence of her opponent. When Chizuko randomly encounters Chroma himself, she does not hold back her complaints against him. For his part, Chroma does not enjoy being defeated again and again; moreover, Fossa Magna will force him to resign if he continues losing. In desperation, Chroma begs Chizuko to become his second-in-command and help him with his evildoings. For the sake of Berry Blossom regaining the spotlight, Chizuko must question whether it is right to join forces with the magical girl's sworn enemy.

Following a bad experience teaching at a public high school that resulted in a break from working, Haruaki Abe eagerly takes up a new job at Hyakki Academy. Despite his cowardice, the novice teacher is motivated to do better this time around. However, his mind quickly changes when he finds out that everyone at the school is actually a supernatural being known as a youkai, leaving him glaringly out of place as the only human around. Facing his class as its new homeroom teacher, Abe immediately becomes a target for the students' antics due to his quick-to-scare nature. Though as the man starts to learn more about the creatures, as well as himself, getting along with the unruly group might not be as hard as he originally thought as their school lives begin to get more vibrant.

Ever since moving into his own apartment, quiet high school student Kei has been looking for a new thrill. He soon finds himself playing mahjong, but his whole life takes a dramatic turn when he is forced to play the game with a criminal group. Even though the odds seem against him, Kei is able to outmatch the others. Instead of claiming his reward in cash, however, he decides to take an abducted girl named Amina under his wing. Due to Kei's skills and cold playstyle, the mysterious Hideharu Seki takes an interest in him, introducing him to mahjong parlors and new potential opponents. But when matched up against an experienced player named Doujima, Kei is severely outskilled and only narrowly escapes going into serious debt. If he wants to protect his new life with Amina, Kei must find a way to outwit these shady characters and come out on top in every game he plays.

In recent years, creatures known as Kaii have frequently attacked cities and wrought destruction. Exterminating these monsters quickly became a popular and well-respected profession, carried out by magical girls. More than five hundred magical girl companies, ranging from small ventures to large corporations, offer their aid to those who need it. Kana Sakuragi is a studious college graduate struggling to land a job despite attending numerous interviews. But when a Kaii attacks during her latest interview, she finds herself assisting the magical girl responding to the crisis. Although she lacks battle experience, Kana relies on her exceptional memory and knowledge to help subdue the monster. Hitomi Koshigaya, the headstrong magical girl who faced the Kaii, recognizes Kana's potential and invites her to join Magilumiere Magical Girls Inc.—the startup where Hitomi works. Wishing to make a difference, Kana accepts the offer to become a magical girl herself. While Kana may not be suited for the corporate world, it soon becomes clear that her true calling is to rise as one of the most talented magical girls in existence.