A world blanketed in an endless and ever-growing ocean of snow. The people eke out a living, either huddled around the roots of enormous trees dotting the surface, or high in the canopy, which spreads over the planet's atmosphere. A chance meeting between Kaina, a youth from the canopy, and Liliha, a young woman from the surface, sets off a chain of events that will change the fate of the world.

D.S.O. agent Leon S. Kennedy is on a mission to rescue Dr. Antonio Taylor from kidnappers, when a mysterious woman thwarts his pursuit. Meanwhile, B.S.A.A. agent Chris Redfield is investigating a zombie outbreak in San Francisco, where the cause of the infection cannot be identified. The only thing the victims have in common is that they all visited Alcatraz Island recently. Following that clue, Chris and his team head to the island, where a new horror awaits them.

Featuring stories from the manga not adapted in the main anime.