At True Cross Academy, Rin Okumura unknowingly comes across the first signs that something is amiss; ordinary people have been gaining the ability to perceive the invisible creatures that roam the human realm, Assiah. While Rin sees this as an opportunity to make a new friend, his twin brother, Yukio, is more burdened than ever. Swamped with his education, exorcist duties, and teaching position, Yukio has remained silent about his awakened powers, unable to understand their scale or significance. While Rin and his friends prepare for the annual Exorcist Certification Exam, the True Cross Order has uncovered the first artificial gate to the demonic realm of Gehenna. Witnessing its size and the advanced technology that made it possible, the exorcists realize they are now dealing with the Illuminati, an extremely wealthy and powerful organization. Moreover, the inscrutable Illuminati have planted three spies in the True Cross Order—and one may be hiding among the aspiring exorcists sworn to protect mankind from the demonic threat.

For hearing-impaired university student Yuki Itose, silence has been a natural part of life since birth. Her world is small and isolated; she commutes to campus, interacts with her best friend Rin Fujishiro, and communicates through writing and text messages—a lifestyle that offers little to no change. One day, during her commute, Yuki meets fellow student Itsuomi Nagi, a multilingual travel enthusiast and friend of Rin. When Itsuomi learns of Yuki's condition, he takes it in stride, moving Yuki's heart. From this one simple gesture, Yuki and Itsuomi's lives start changing day by day as they let each other into their own worlds.

Satou has been in love with his childhood friend and neighbor, Hime, ever since she and her grandfather appeared out of nowhere 10 years ago. Now a dazzling, yet mysterious high school beauty, she makes it more and more difficult for him to confess his feelings. As the anniversary of their first meeting is nearing, will he muster up his courage to transform their friendship into something more? Or will an entirely different fate await this tightly bonded pair?

In Tokyo Fire Department's Fire Academy, a talented new rookie is excelling in the strict and grueling rescue training. With high proficiency in both physical and mental categories, Daigo Toake is envied by one of his peers, Shun Onoda. Despite feeling a growing sense of rivalry, Shun recognizes that a part of his jealousy stems from his admiration for Daigo, and that they will eventually work together for the same noble goal of rescuing people. At the same time, Yuki Nakamura is the only woman among the current batch of recruits. She believes that she will not be outclassed in this male-dominated profession. As the fates of the three newbies intertwine, they may soon realize that the intensity of a real disaster is nowhere near what they have experienced in training. Even so, the heroes in orange will always shine brighter than any fire, saving those in need.