Thirteenth episode delivered as a bonus Blu-ray disc to customers who pre-order all six Blu-ray volumes.

After escaping the zombie-infested mainland, Takashi Komuro and the gang find themselves on a remote island off the coast of Tokonosu City. While scavenging around the island for supplies, they encounter a small seaside shack that provides them with clothing and a place to rest for the night. After a day's work of collecting food, they begin to cook what they have gathered. As they wait beside the campfire, a light haze begins to form around them and makes them nauseous. Confirming it to be caused by hydrangeas—a type of poisonous plant that can cause hallucinations—the group attempts to escape from the powerful odor.

After centuries of antagonism and misunderstanding, the Japanese finally welcome youkai into their community. In an attempt at species integration, normal children begin attending school with paranormal creatures who are quite humanoid. Shingo Ohashi finds himself developing feelings for Hatoko "Petoko" Fujimura, a half-youkai half-human girl whose powers are: uncontrollable cuteness to enchant those around her (similar to a low-power succubus), get stuck to any other person who touches her bare flesh (cured by her falling asleep), and the ability to disappear even at the molecular stage (which she can for the most part control). (Source: The Anime Encyclopedia)

As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.