Toujima Tanzaburou has spent his entire life chasing a dream: to become Kamen Rider. Now, at 40, reality has nearly caught up with him, and he's on the verge of letting go of his childhood fantasy. That is, until he gets caught up in a crime wave led by the "Fake Shocker" gang—turning his long-time dream into something far more dangerous. What starts as a pretend hero's journey quickly becomes something real. The ultimate Kamen Rider fantasy is about to begin!

Let's walk and talk. Can you get up? The Gnosia lie. Pretending to be human, they'll get in close, trick and deceive, and then eradicate each person in the vicinity from the universe, one victim at a time. The crew of a drifting spaceship, facing off against a mysterious and deadly threat known as the "Gnosia" and having no idea who among them is really the enemy, formulate a desperate plan for survival. The most suspicious among them will be put into "cold sleep" one by one, in an effort to completely rid the ship of Gnosia. However, it is almost impossible to tell whether each person put into cold sleep was really Gnosia—or simply a poor, unfortunate scapegoat, sacrificed by the Gnosia for their own survival. Can the humans emerge victorious? Or is mankind doomed...?

In the beginning, an "orb" is cast unto Earth. "It" can do two things: change into the form of the thing that stimulates "it"; and come back to life after death. "It" morphs from orb to rock, then to wolf, and finally to boy, but roams about like a newborn who knows nothing. As a boy, "it" becomes Fushi. Through encounters with human kindness, Fushi not only gains survival skills but grows as a "person". But his journey is darkened by the inexplicable and destructive enemy Nokker and cruel partings with the people he loves.

Despite occasional setbacks, Operation Strix has remained on track to extract sensitive information from the enigmatic politician Donovan Desmond. To this end, spy Loid Forger has managed to maintain his pretend family consisting of his telepathic daughter, Anya; assassin wife, Yor; and their clairvoyant dog, Bond. Still the only one aware of everyone's true identities, Anya tries to sustain the family's cohesion while working to befriend Donovan's son Damian, her Eden Academy classmate. However, Anya's efforts instead earn her another Tonitrus Bolt, bringing her closer to getting expelled and jeopardizing the operation's success. Hearing the news, Loid faints from shock. In his unconsciousness, he reminisces about his tragic past and his journey to becoming a spy. Realizing what Operation Strix means to him and the world, Loid finds renewed motivation. Although they each work toward their own covert goals, the Forgers continue to cherish their chaotic yet blissful family life.