Ron Kamonohashi, the best student in the history of the elite Detective Training Academy BLUE, has been living as a recluse since BLUE expelled him five years ago. Moreover, he is forbidden to work as a detective, having barely escaped execution after getting involved in a murder case while he was still attending the school. Ron's situation changes drastically when police detective Totomaru Isshiki, following the advice of a senior colleague, seeks him out for help with a criminal case that has remained unsolved for months. Ron reluctantly agrees to help Totomaru and uses his phenomenal intuition to discover the culprit in less than a day. However, it appears that Ron suffers from a mysterious condition that can cause those around him to lose their lives. To Ron's great surprise, Totomaru manages to save the life of someone whom Ron put in jeopardy. As the unlikely duo starts solving crimes one after another, BLUE sends operatives after its former student to find out if he has resumed investigative work. Fighting against murderers, rogue detectives, and the Metropolitan Police Department, Ron and Totomaru must join forces if they want to survive and see justice prevail.

Osamu and Youko Sonoyama want more than anything to adopt every child from Soramame House, but the wealthy couple can only pick one due to their increasingly old age. While they contemplate this delicate decision, one child's alluring beauty and gentle soul instantly draw them in. Two months later, the Sonoyamas welcome 13-year-old Hitori into their warm and loving home. However, Hitori's humble and overly polite exterior is merely a masquerade. In reality, Hitori is a carefully crafted character played by identical twins Migi and Dali. For them, being the ideal child of this kind couple is merely a stepping stone to infiltrating a certain quiet town. While dutifully protecting their cover, the twins work toward their true objective: to discover the truth behind a past incident that left them with a burning desire for vengeance.

Fifteen-year-old Umika Konohoshi is having a hard time socializing at school, but she hopes her words will someday reach other people. When self-proclaimed alien Yuu Akeuchi enters her life, Umika will learn more about being open.

The story is set in a world where the value of Bikkuri-Man stickers are so high that they have to be transported in a cash transport vehicle. There was also the famous robbery case one year ago, called the "300 million Bikkuri-Man sticker case." One day, a high-school delivery part-timer named Yamato gets involved in a battle over stickers between two competing convenience stores. The Angel Mart owned by the Phoenix store manager is famous for its easy-to-use glitter stickers. The Devil Store across the street also tries to attract Bikkuri-Man fans to their store. Former comrades are divided into allies and foes, and the battle of destiny begins.