Gekkan Mousou Kagaku is set in Most City in an unknown country in a small publishing house that prints a monthly magazine about the most outlandish of things. Everything changes when the staff of the magazine, editor-in-chief Tarou, his assistant Jirou and dog Saburou, meet with scientist Gorou Satou...

Year 1874,. Shizuma Orikasa, once a samurai of the Aizu Domain and now working as a rickshaw puller, embarks on a quest to locate his missing fiancée, Sumie Kanomata. However, an unexpected turn of events thrusts him into the ranks of the newly established police force, entangling him in the pursuit of a conspiracy aiming to topple the government. Simultaneously, the Moriya yakuza clan welcomes a guest, Kyoshiro Shuragami, a proficient swordsman. Within the clan, which is linked to the mastermind orchestrating the government overthrow, Kyoshiro strategically positions himself for personal gain. This sets the stage for the unfolding drama of destiny between Shizuma and Kyoshiro, where ironic encounters and separations await Shizuma in the course of his journey.

Located five stations away from Hokkaido's largest downtown area Susukino. A fun shop called "Snack Bus" can be found run by mama Basue and mama Akemi. Filled with the laughter of the girls and their unusual regulars, you'll be smiling along with them before you know it.