After the Li Zhu Grotto-Heaven collapses, Chen Ping’an takes on a great responsibility to escort Li Baoping and the others to Great Sui to study. Their journey is extremely dangerous, with enemies and supernatural threats along the way, but they receive help from the mysterious swordsman A Liang and other powerful figures. Traveling far and fighting countless battles, the young man grows stronger while learning the weight of responsibility.

Amidst a blizzard caused by UMA Winter, Billy receives a report on the Autumn battle and learns Undead and Unluck are evolving. Juiz appears, revealing to him that the artifacts are weapons meant to defeat God and that the Ark can only perform one more loop. She urges Billy to join forces once more and stake everything on Unluck to achieve their shared goal: "defeat God." However, Billy declares that they cannot work together. Juiz realizes Billy's true intention—to obtain Ark and Apocalypse—but before she can act, Billy drags them into a brutal clash involving UMAs on both sides. Resolute in their own "justice," Juiz presses forward with her blade, while Billy counters by utilizing other Negators' abilities and his pistol. What is Billy's true objective? Meanwhile, Andy and Fuko, having captured Autumn's core, are en route by air to take down Summer. But Billy anticipates that Juiz entrusted Apocalypse to Andy, and sends assassins to strike the pair from the skies!

Following the First-Class Mage Exam, the trio—elven mage Frieren, warrior Stark, and first-class mage Fern—gains access to the dangerous Northern Plateau. As the party presses onward toward Aureole, formidable adversaries force Stark to confront his insecurities, solidifying his resolve and his role as the party's frontliner. Meanwhile, Fern continues to cherish the gifts she has been blessed with throughout her life, each a reminder of those she holds dear. Frieren—still honoring her vow to understand humanity—revisits memories of her journey with the Hero's party and her fleeting encounter with a legendary figure. As she reflects on the passage of time, the elven mage quietly questions whether she has truly changed, yet in the small, almost subtle choices that she makes, there are signs that she might have become more human than she realizes.

Seeking the key to the elixir of immortality, the group arrives at the fortress of the island's monstrous ruler, the "Tensen." To survive and escape the island, cooperation becomes essential—regardless of whether one is a condemned criminal or an executioner. Meanwhile, the shogunate orders additional landings on the island of the Immortal Realm, led by Shugen Yamada Asayemon. Among them are the Ishigakure clan, who share a past with Gabimaru. Desperate to find the elixir and escape the island, Gabimaru and his companions face the Tensen in a battle that escalates into an all-out confrontation between humans and immortals!