​On the island of Regalo, a group of supernaturally powered mafia-like protectors called the Arcana Famiglia safeguard the people from any who would harm them. The members of their organization, having made contracts with tarot cards, each possess different abilities, such as overwhelming strength, invisibility, or the power to see into someone's heart. Mondo, their leader and the "Papa" of their family, announces at his birthday party that he will be retiring soon. He plans to hold the Arcana Duello, a competition that, if won, will grant the winner the title of Papa and any wish they desire. But there is more at stake than just a title: Mondo also decides that the winner will marry his daughter, Felicità. Enraged by this, the strong-willed Felicità decides to enter the competition herself, in order to make her own way in the world. As Felicità battles for her freedom, her competitors battle for her heart.

The year is 2027 in MegaTokyo, six years before the Knight Sabers will make their debut. Boomers (artificial humans) are still a relatively new advancement, and the implementation and integration of boomers into society is still a bit buggy -- sometimes fatally so. Whenever a boomer incident occurs, though, there is the Advanced Police, a special force trained to deal with boomer crimes. Leon McNichol is a rookie in the AD Police, and is just starting to become exposed to the horrors and tragedies one finds every day in MegaTokyo. He and his veteran partner, Gina Marceau, slowly learn about the ever-fading line that separates man from machine.

A-ko and B-ko are bounty hunters in an untamed world. When a young heiress, C-ko, falls out of the sky and into their hair, they find themselves battling space pirates and galactic police. Turns out the high-pitched, hungry C-ko holds a secret—the spirit of an ancient evil—and is the center of a plot to destroy the universe!