The plot of this OVA is a rough adaptation of the first four chapters of the Guyver manga. It covers the same basic elements of these chapters; Genesis of the guyver, Fight with Vamore, Fight with Guyver 2 and the introduction of Guyver 3. Main differences are the exclusion of Tetsuro and his replacement by Mizuki, The replacement of Lisker with a female Agent "Valcuria", and thus a female Guyver 2. There is also a look at Sho's psychology of how he deals with his situation including a very harsh moment where his friends are assassinated in cold blood. One night, high school student Sho Fukamachi discovers a mysterious metal object. Then in a blinding flash of light, Sho finds that he has accidentally fused with the Guyver, a mecha of mysterious alien design. Now, to save his girlfriend, Mizuki Segawa, along with the entire world, Sho must become the Guyver to fight the Chronos Corporation and their biocreatures, called Zoanoids, who are hell-bent on world domination.

In the story, the protagonist Youtarou Misaki finds himself lying on the beach one day. He is picked up by Arashi, who manages a restaurant called Kurage no Shokudou. When asked who he is, the protagonist tells a lie that he lost his memory—but he remembers everything, including the fact that his twin brother died.

Short 3D CG Specials included in the Blu-rays of the Ghost in the Shell: Arise movies.

Short episodes with super-deformed characters posted on the official Twitter account. Includes three extra collaboration episodes with halca, the peggies, and eheya.