Based on Team Shanghai Alice's Touhou Project. History revolves around the many events in the lives of two students from the Outside World - Maribel Hearn and Renko Usami. They are the only members of the "Hifuu Club Activity Record" who are looking for those hidden worlds as Gensokyo, the Netherworld and the Moon.

The year is 2052—an era of unprecedented peace and prosperity prevails across the globe. The reason for this: mankind has been freed from sickness and pain. Nobel Prize winning neuroscientist Dr. Skinner has developed a miracle cure-all drug with no apparent drawbacks called Hapuna. Hapuna soon becomes ubiquitous... and essential. However, soon after Hapuna is officially introduced, Dr. Skinner vanishes. Three years later, the world has moved on. But Dr. Skinner has returned—this time, as a harbinger of doom. Skinner announces that Hapuna has a short half-life. Everyone who has taken it will die approximately three years later. Death is coming for this sinful world—and coming soon. As a response to this threat, a special task force of 5 agents is gathered from across the world to save humanity from Skinner’s plan. This group is called "Lazarus." Can they find Skinner and develop a vaccine before time runs out?

Welcome to the fascinating world of Gensokyo, in which youkai (A term for all sorts of spiritual creatures), animals and some humans live, completely separated from our world by a magical barrier. The only gateway between the two worlds is the Hakurei shrine. Reimu Hakurei is the maiden working at said shrine. Whenever problems of supernatural causes (known as "Incidents") occur, Reimu goes out with her friends to investigate, eliminate the cause and hopefully restore Gensokyo to its equilibrium.

Sequel to Uchuu Senkan Yamato 2205: Aratanaru Tabidachi.