In a world where death is not permanent, Terakomari "Komari" Gandesblood has been a self-proclaimed professional shut-in for the past three years. As part of the noble Gandesblood lineage, she once tried to meet the expectations of her family. However, as a vampire who cannot use magic or consume blood, she soon gave up on becoming an imperial general like her ancestors. Unfortunately, a misunderstanding with her father earns her the formidable position of one of the Seven Crimson Lords, the strongest fighters and generals in the Mulnite Empire. Now, Komari must hide her lack of talent from the soldiers she commands, or they may attempt to overthrow her. Working alongside her newly-assigned maid, Villhaze, Komari manages to trick her unit of soldiers into believing she is a ruthless warlord and promises to conquer the world. But as more people come to admire Komari, her life is further threatened as a vampire from her past reappears with every intention to kill her for good.

In order to take over her grandmother's Dagashi store, art student Kumi Honamanuma moved to Kyoto. She met Harami Mino, K Kusanagi, Mai Haisaka, and a dog who lives in the store, which supposed to be empty. Kumi ended up living with these girls, who claim that they are heroes reincarnated to contemporary period to chase after the demon king. Harami and others seem to live in a peaceful life with no missions to to do anymore, Ran, who was demon king in the past and appears to be an elementary school girl from failing to reincarnate, one day. The story begins with Ran requesting to collect demon king's fragments.

Spirits have always been attracted to Keitarou Gentouga due to his strong spiritual presence. A traumatic encounter with one had caused his right hand to be cursed, forcing him to wear a glove at all times. Now a college freshman, Keitarou is trying to live as normal a life as possible. With the encouragement of his childhood friend Eiko Houzuki, he becomes a private tutor. Since he is at the top of his intake class, his first client is the tutoring firm's most promising student, Yayoi Houzuki. To Keitarou's surprise, Yayoi is Eiko's cousin, and she possesses two pupils in each eye—allowing her to see into the spirit world and purposely seek vengeful spirits to exorcise. Ever since a car accident killed both her parents, Yayoi has been searching for the powerful spirit that kidnapped her mother's departed soul. Seeing that spirits are so attracted to Keitarou, she ropes him into helping her collect other evil spirits that will assist in her future fight. Although her quest is dangerous, Keitarou reluctantly decides to join her, even as each new spirit they meet has him questioning his resolve at every turn.