The plot of Open Your Mind follows the extraterrestrial origin of life, coming from outerspace as six deities (Intermission act), evolving into water (Sho-ho) then emerging to the air (Hyakkin) and to the ground (Ku-nu). Each one of these creatures rules one of the six elements of the godai philosophy, i.e. Earth, Water, Fire, Wind (referred to as kaze in the Hyakkin chant), Sky and Consciousness (referred to as "Awakening" in the movie's title).

Following the popularity of the original omnibus OVA, this release offers 4 more stories but in animation only.

Naoko-san is an alien from the planet Yuri, who is plotting to conquer the Earth by yurifying it. Misuzu is a junior high girl and is always troubled by Naoko-san, who lives on the roof of her house.

After inheriting the company from their parents, siblings Yuuhi and Yuamu Oudou have started to work at Ultraterrestrial Trouble Solutions, an organization that hunts aliens. Although they have never encountered aliens before, Yuuhi is desperate to meet one as he believes that an alien has stolen his important item called the "Earthdamar." One day, while searching for extraterrestrial creatures, Yuuhi and Yuamu find a strange spot in the forest where many trees have fallen, forming a scenery similar to a crop circle. As they venture further, they discover a mysterious spaceship and enter it out of curiosity. To their surprise, they come across Yudias Velgear, an alien from the Velgear Star Cluster. As it turns out, Yudias is seeking to learn about Rush Duel—a card game popular among elementary school students—as he believes that it will save his home from a long war. With the siblings agreeing to teach Yudias about Rush Duel, they eventually realize that their first contact with an alien may not be a random coincidence.