Saito Hiraga and Louise Françoise Le Blanc de La Vallière go on the offensive after the events of Zero no Tsukaima: Princesses no Rondo. Together, they face off against King Joseph in the Holy City of Romalia with the help of two others who control the power of the “void”. But in the midst of the many conflicts ahead of them, an ancient evil begins to stir in the shadows. Will their close bonds blossom into something more or will they be shattered through the ever increasing difficulty of the tasks that they must undertake? Zero no Tsukaima F follows the story of Louise and Saito as they face their final challenges together.

Chuuta Kokonose is an orphan who lives with his aunt. For as long as he can remember, he's had a voice in his head, but other than that he's a normal boy—right until the day when a strange-looking thing follows him home and teleports him to a place filled with more fantastic creatures. It's a space police station, and Rein Brickke, the Chief of Solar System Department, tells him that he's been chosen by the computer as a possible candidate to join the police force. Misuzu Sonokata, a girl from Chuuta's school with an angelic face and ill temper who turns out to be one of Rein Brickke's subordinates, doesn't think him suitable for such a job. Chuuta, who was shocked at first, decides to take the aptitude test after being urged by the voice in his head and to prove Misuzu wrong.

As soon as he entered high school, the first year student Koshiyama Shiki was invited to the mysterious Quiz Study Group led by his senpai. What will Shiki run into when being dragged along by his class mate Mari into the dazzling world of competitive quizzes?! (Source: Comic Walker)

Sena is like any other shy kid starting high school; he's just trying to survive. Constantly bullied, he's accustomed to running away. Surviving high school is about to become a lot more difficult after Hiruma, captain of the school's American football team, witnesses Sena's incredible agility and speed during an escape from some bullies. Hiruma schemes to make Sena the running back of his school team, The Devil Bats, hoping that it will turn around the squad's fortunes from being the laughingstock of Japan's high school leagues, to title contender. To protect his precious star player from rivaling recruiters, he enlists Sena as "team secretary," giving him a visored helmet and the nickname "Eyeshield 21" to hide his identity. The Devilbats will look to make their way to the Christmas Bowl, an annual tournament attended by the best football teams in Japan, with "Eyeshield 21" leading the way. Will they be able to win the Christmas Bowl? Will Sena be able to transform from a timid, undersized freshman to an all-star player? Put on your pads and helmet to find out!