The Wonderful Precure! anime is set in Animal Town, a town where animals and people live together in harmony. Second-year junior high school student Iroha Inukai is best friends with her dog named Komugi. Out for a walk one day, Iroha and Komugi encounter a mysterious creature named Gargal, who goes on a rampage in the city. Komugi suddenly transforms into a Pretty Cure named Cure Wonderful, to protect Iroha.

The kind and compassionate heroine of an otome game may be as flawless as she is admirable, but a certain young woman from Japan much prefers the villainess, Alicia Williams. She sees sense in Alicia's ruthless verbal abuse and values her discipline and fortitude. On the other hand, aside from always toying with Prince Duke Seeker's emotions, the commoner heroine seems to only spout lip service. Given the choice, the young woman would love to be reincarnated as Alicia—and her wish suddenly comes true! Seven-year-old Alicia awakens with the memories of her past life, now aware of all the future events, outcomes, and the world's secrets. She has no fear; to outsmart the heroine and avoid a bad ending, all Alicia needs is hard work, mastery of her noble family's dark magic, and the determination to become the greatest villainess in history.

As a young child, Takashi Natsume believed his ability to see youkai to be nothing but a curse. Now a high school student, Natsume has managed to heal from his old wounds and form unbreakable bonds with humans and youkai alike. Natsume's newfound friendships—including the one with his spirit bodyguard Madara, nicknamed "Nyanko-sensei"—are often interlaced with his duty to return the names of the spirits written inside the Book of Friends, his late grandmother Reiko's keepsake. While more remarkable youkai reach out to him, Natsume discovers that he still has much to learn about the world that surrounds him.

For over one hundred years, a special quest has been waiting for a wizard skilled enough to complete it. On the northern continent of Guiltina, there are five immensely powerful Dragon Gods who possess great destructive force that can only be quelled by sealing them away. Natsu Dragneel and his friends from the Fairy Tail guild—Lucy Heartfilia, Gray Fullbuster, Erza Scarlet, Wendy Marvell, and the exceeds Happy and Charlés—consider this the perfect challenge to take on. The Fairy Tail mages are not the only ones searching for the Dragon Gods. Diabolos, a guild exclusive for "Dragon Eaters," seeks to enhance their Dragon Slayer magic by devouring the dragons. Meanwhile, Fairy Tail's newest addition, Touka, appears to be hiding something sinister from her new companions—and her secrets may bring disaster to the guild while its strongest wizards are away.