Kou Yamori is an average middle school student who struggles with grasping the complex concept of love. Because he sees little sense in surrendering to the norm, he soon stops going to school. Plagued with insomnia due to his idleness, Kou begins roaming the lonesome streets at night. One night, Kou encounters a bizarre girl named Nazuna Nanakusa who believes that people stay awake during the night because they are dissatisfied with how they spent their day and cannot rest until they release their inhibitions. Nazuna offers to help Kou with his sleep issues and invites him over to her place, where she convinces him to share a futon with her. Feeling uncomfortable, Kou only pretends to doze off—which is when Nazuna suddenly bites his neck and reveals herself to be a vampire! While Kou thinks the bite will turn him into a vampire, the specifics of transforming are not that simple. In order to change, he must be bitten by someone he truly loves. Ready to let go of his dreary mortal life, Kou decides on a new goal: he will fall in love with Nazuna and become a vampire.

Under the guidance of Tang Zichen, a master of martial arts, Wang Chao, a frail young man with a strong sense of justice, embarks on the road of traditional martial arts and goes all the way to surpass himself. He experienced the spirit of martial arts practitioners who use martial arts to stop stances and convince people with morality, and also carry forward traditional martial arts and promote righteousness.

The anime revolves around a boy named Cota Coga (a wordplay on Coca-Cola) who strives to be the world's best Bottle King at the Bottle Battles in the virtual Drink World, with his Bottleman partner Colamaru and battles with various rivals. Bottleman! A new entertainment that has revolutionized the world! In the virtual space, Drink World, people use Bottleman to do bottle battles with one another! All strong bottle fighters aim to be the Bottle King!