The seemingly eternal cat-and-mouse battle has ended, and now everyone is living peacefully. One day, an Eto-musume (Zodiac girl) named Na-tan appears, to the puzzlement of the 12 signs, and to the unreserved delight of Nya-tan (whose spirits are always lifted by the pure, straightforward Na-tan). Meanwhile, Chu-tan also appears and warns of a looming disaster. "The seal… has been broken." Who is this mysterious Eto-musume Na-tan? What in the world is the deity that has awoken beneath the seal?

On Halloween night, a young chimney sweep named Lubicchi befriends a man magically conjured out of garbage. Giving him the name Poupelle, Lubicchi is able to recreate a bond he lost when his father died to the tyranny of the Inquisitors—an oppressive force that aims to suppress outside knowledge and the town's true history. But their newfound relationship soon captures a lot of attention, and the threat of the Inquisitors and even the criticism of a few townspeople will test the duo's friendship. In spite of this, Poupelle has struck a particular chord with Lubicchi, and the two conspire to bring the truth to the surface and clear the chimney smoke that clouds the town's skies.

The series centers on Joelle Davidovich Pomponette (Pompo-san), a talented film producer at the movie capital "Nyallywood." Despite her prowess to see through to the potential of actors and staff and bring out their talent to the fullest, she has only been producing B-class action and erotic films. One day, Pompo's "film-worm" assistant Gene, who has been doubtful of her choices of film genres, is given the task to direct a film based on a script written by her. Will Gene be able to bring Pompo's "masterpiece" to fruition?

At Granbell Kingdom, an abandoned amusement park, Shiki has lived his entire life among machines. But one day, Rebecca and her cat companion Happy appear at the park's front gates. Little do these newcomers know that this is the first human contact Granbell has had in a hundred years! As Shiki stumbles his way into making new friends, his former neighbors stir at an opportunity for a robo-rebellion… And when his old homeland becomes too dangerous, Shiki must join Rebecca and Happy on their spaceship and escape into the boundless cosmos. (Source: Kodansha Comics) Episodes 1-2 were streamed in advance on March 29, 2021. Regular broadcast began on April 11, 2021.