Based on the long cherished, classic Japanese novel Nanso Satomi Hakkenden by Bakin Kyokutei Takizawa (1767), a modified version of it was made into animation. Taking place in the future, during this time wars were occuring in heaven, mostly for possession between the eight moons created by the savior Fuse that surrounded God's land. When the war ended, there was only one ruling family - that of the Oowaris, and the remaining son gained control of all the moons of heaven, except for one. Meiten, the moon of the pope, where people refrained from war and were therefore out of it's terms. Eight people. Each from one of the eight moons. Each possessing one of the jewels - the elements that compose Earth. They are those who are destined to become saviors of humanity. All of them have sacrificed for these jewels, and are determined to complete their duty to Queen Fuse who entrusted these to them. When the mad emperor Kai threatens to revive a ghost who wants to prevent the restoration of Earth, these eight must battle using the powers given by their jewels in order to create Earth and defeat those who want to prevent it. So they all go to Kusanagi, the ship in the center of God's land. They must gather the jewels in the key called Yatsufusa at Kusanagi's center, in order to create Earth.

Sho Fukamachi, a normal teenager accidentally found an alien object called Unit and thus, changed his life forever. The Unit bonded with Sho, resulting in an incredibly powerful life-form called Guyver. With this great power, Sho battles the mysterious Chronos organization and it's Zoanoids, in order to protect his friends and his world. Unknown to Sho, the battle against Chronos will lead to the discovery of the origins of human, their destiny, and the Creators...

The ancient kingdom of Parros has been invaded by the armies of Mongaul, and its king and queen have been slain. But the "twin pearls of Parros," the princess Rinda and the prince Remus, escape using a strange device hidden in the palace. Lost in Roodwood, they are rescued from Mongaul soldiers by a strange leopard-headed man, who has no memories except for the words "Aurra" and "Guin," which he believes to be his name.