Akazukin Chacha is the story of a young magical girl (Mahō Shōjo) named Chacha. Living with her guardian in a cottage on Mochi-mochi mountain is Seravi, who is her teacher and also the fictional world's greatest magician. Chacha is clumsy in casting her spells because, throughout the anime, when she summons something, it often turns out to be something that she didn't mean to cast, for example, spiders (kumo) instead of a cloud (also kumo). At times in the anime when she and her friends are in trouble, however, her spells do work. Living on the same mountain is a boy gifted with enormous strength named Riiya. It is described that Riiya came from a family of werewolves who can instantly change into a wolf whenever they want. Quite far from Mochi-mochi mountain lies Urizuri mountain. Dorothy, also a well known magician in her land, lives in a castle on Urizuri mountain. Living with her is Shiine, her student. Shiine is adept when it comes to casting spells. He is a young wizard and most of his knowledge about magic was taught to him by Dorothy. The first 2 seasons were originally created by the anime team. Most of the stories in season 3 are based on the manga.

In the year 2010, the Japanese radio industry is in decline. To reverse their flagging ratings, a station staffed with perennial losers makes a daring gamble: to hire the industry's first android on-air host. Maico is cute, but it will take more than novelty to win over the fickle audience -- especially with a crew as inept as this one.

Nanako is a an inept apprentice nurse to the brilliant young Dr. Kouji. Now for some reason, Nanako is always being targeted by various elements which makes Nanako wonder if she has done anything wrong. But there are certain secrets to Nanako's past that only Dr. Kouji and his family know about.

Japan is secretly controlled by a tyrannical group of ninjas called the Shinogara. Their finest assassin is a man named Hayate Kanuma, whose father leads the Shinogara. Hayate, however, knows that the secret society's control over Japan is wrong. Sacrificing his own safety, Hayate kills his father. Now he's on the run, safe almost nowhere from his vengeful former comrades except perhaps for the one hiding place he decides upon: his sister. After possibly being fatally wounded, Hayate is able to transfer his soul into his sister's body, temporarily sharing it with her. His sister, Shiori, can awaken Hayate and call upon his ninja abilities when the Shinogara are close at hand but each time she does so, a little more of her true self is lost. This arrangement can't possibly go on forever, so how will Hayate finally defeat the Shinogara?