After living peaceful days at the Kamiya dojo, Kenshin Himura finds himself at a crucial crossroads, as his vow to never end a life is put to the ultimate test. Following the murder of his former commander, he now has to retread the road of violence and blood to take down Makoto Shishio—the assassin prodigy who calls himself the notorious Battousai's successor. With ambitions to overthrow the Meiji government and establish his dominion in Kyoto, Shishio has meticulously schemed for a decade, building a formidable anti-government military force. Now, Shishio has turned his sights toward recruiting Aoshi Shinomori, a cold-blooded killer and the former leader of the legendary Oniwaban Group warriors. As Kenshin travels through a village abandoned by the government and currently under the iron fist of Shishio's henchmen, he is determined to prevent the country from spiraling back into civil war. He allies with his former rival, Hajime Saitou, forging a fragile partnership in a battle against Shishio's empire that will determine the fate of Japan.

Five hundred years ago, the fantasy world of Alneath was torn apart by a war between magically gifted immortals and mortals armed with magical artifacts. The conflict came to an end when mortals' hero, Gram, slayed the Demon Lord Veltol Velvet Velsvolt. In 2099, the world looks a bit different. Alneath and technologically advanced Earth have fused in an event known as Fantasion. Immortals have been hunted down to near extinction, and technological implants called Familia allow mortals to use magic. As the new world slowly recovers, Veltol's vassal Machina Solege resurrects him in Shinjuku, a techno-magical city constructed in the middle of devastated lands. However, Veltol's magic is severely weakened, and his former ally Marcus has betrayed him. To regain his fame and magical abilities, Veltol follows the advice of Takahashi—Machina's friend and a professional hacker—to start an unusual career: live streaming. His sharp tongue and comically poor gaming skills quickly secure him followers, but to dominate the world once again, Veltol must first uncover Shinjuku's secrets and thwart Marcus' vile plans.

After witnessing his mother's death at a young age, Uryuu Kamihate grew up disillusioned with the gods, dismissing faith in them as utter nonsense. Due to his beliefs, he aims to become a doctor, spending most of his time studying to enter the prestigious Kyoto University. To further his studies, Uryuu searches for a new place to take him in and get away from the noisy environment of the orphanage where he grew up. Chidori Amagami, head priest of the Amagami Shrine, allows him to stay at the Amagami residence. However, Uryuu has to live there with Chidori's three granddaughters—Yae, Yuna, and Asahi—who serve as shrine maidens. Moreover, Chidori has another condition for Uryuu: he has to marry one of the sisters to ensure the shrine's future and one day inherit it. But with Uryuu's goals and outlook naturally clashing against the sisters' beliefs, this already daunting ordeal seems outright impossible.

High school student Haruka has always been a content loner. One day, he and his class are abruptly transported to another world and given skill points to use when choosing from an assortment of abilities and magical powers. Unfortunately, Haruka arrives last, and he can only use his points on the seemingly impractical abilities the others had no interest in. Although he is on his own again and must adjust to his new life by himself, he much prefers it that way. However, Haruka's peaceful solitude is short-lived, as he runs into some of his classmates. Weak to their pleas for help, he ends up sheltering and helping them reunite with the others. But the different cliques struggle to see eye to eye, forcing Haruka to find a way to end the infighting and restore harmony between them to survive the unfamiliar world.