In his laboratory, biotechnology expert Dr. Kochin gathers the dragon balls intending to free his master Dr. Uirou, a mad scientist hellbent on ruling the world, forever frozen in the never-melting ice of the Tsurumai-Tsuburi Mountains. Attempting to locate the dragon balls, Gohan Son and Oolong arrive at the scene and are ambushed by several creatures known as "Bio-Men." Training nearby, Piccolo attempts to save them but is then attacked by three mysterious warriors. When the ice beneath them breaks, it cuts their altercation short, burying Gohan and Oolong within.

After regaining consciousness, they return home to Kame House only to encounter Bio-Men, demanding Muten-Roushi to follow them. Refusing, he easily defeats the creatures, piquing Dr. Kochin's interest. Under the impression of Muten-Roushi being the strongest man in the world, Dr. Kochin takes Bulma hostage, forcing Roushi's agreement to accompany him in mysterious plans involving his master. Who are Dr. Kochin and Dr. Uirou? What even is their purpose?

[Written by MAL Rewrite]

Yamato Akitsuki travels to Tokyo alone to study in one of the high schools located within the area. He lives in with his aunt who operates a public bath solely for the ladies in the local district and begins his normal high-school life. One day, he chances upon a girl in school and is immediately mesmerized by her beauty. He is shocked when he realizes later that the girl, Suzuka, is actually living next door to him. From then on, Yamato's ordinary life begins to change little by little.

The Fourth Industrial Revolution has led to the development of cutting-edge technologies that have rapidly evolved the world. As a result, schools have begun incorporating these technologies into their curriculum, leaving behind the ways of the old. One such institution is the elite Yuyu Girls' Vocational High School, where both Serufu Yua and her childhood friend, Miku "Purin" Suride, have applied. Although the tech-savvy Purin is accepted to Yuyu High, the accident-prone Serufu is rejected and enters the traditional Gatagata Girls' High School instead, driving a wedge into their friendship. On her way to class one day, Serufu gets into a bike accident, and Rei Yasaku, a passerby who attends the same school, fixes her damaged bicycle. Serufu later finds out that Rei has a passion for old-fashioned crafts and is the head of the school's Do-It-Yourself (DIY) Club—which is in danger of closing due to a lack of members. Realizing that this may be her chance to repair her relationship with Purin, Serufu joins the club in hopes of creating projects that could bring them together once more. As the DIY Club welcomes new faces, Serufu learns to build not only handicrafts but also new friendships along the way!

Haruki Nakano lives an average high school life, except for the fact that his mother is overseas and he shares an apartment with his four sisters. There's the oldest, Mutsuki, who has a bad habit of falling asleep in his bed, the junior high school student Yayoi, who hits him whenever something happens, and then the grade school twins, Uzuki and Satsuki, who love to play pranks on their older brother. Stuck in a house with four girls, Haruki has to deal with all sorts of trials. From going grocery shopping, watching scary movies, to kissing practice, life is never boring in Danchigai!