A world where it has been established that people routinely swing between slightly different parallel worlds... Koyomi Hidaka, who lives with his father following his parents' divorce, meets a girl named Shiori Satou at the research institute where his father works. They both have a little crush on each other, but everything changes when their parents remarry. Koyomi and Shiori, convinced that they will never be together, try to jump into another world where they won't be step-siblings... There's no meaning in a world without her.

While mahjong is a game that is often played with family and friends, it is also a game that is played in the darkest corners of society. Nangou is a compulsive gambler who has accumulated debt over three million yen. In a last ditch attempt to clear his record, he decides to wager his life on a game of mahjong with the mafia. Unfortunately, as the game progresses, Nangou only moves further from the prize and closer to death. When all hope seems lost, the game parlor is suddenly intruded upon by Shigeru Akagi, a young boy on the run from the police. Desperate to turn the game around, Nangou hands the game over to Akagi after teaching him a few of the rules. The mafia can only smirk as Akagi sits down to play. However, they soon come to learn that Akagi is a natural-born gambler. An imposing figure who does not fear death. One who is destined to become a legend. [Written by MAL Rewrite]

As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.

In a fantasy world where "jobs" are god-given from birth, heroes are born, not made—and Ein's job of "Appraiser" has put him about as far from the "hero" pedestal as possible. Used, abused, and eventually abandoned by his fellow adventurers, Ein decides it just isn't worth going on. Lucky for Ein, though, the end may just be the beginning, as well as a new lease on life. Turns out, his "worthless" job may just be the key to becoming a hero after all.